The giant Salmonflies of the Western mountains are legendary for their proclivity to elicit consistent dry-fly action and ferocious strikes.
Someone coming to my river from down the road without the info I had was at a decided disadvantage.
One day I said to myself, to hell with this streamer crap that’s too much like bait fishing (take it easy on me guys), and I never went back.
I believe that no matter how good you are “some days it’s diamonds and some days it’s stones”.
As to any particular water causing "target panic". Learn to ignore it.